Ammonia → 2-Isopropyl-5-oxo-1-imidazolidineacetamide

HRID 256373ノート

反応式

HRID 256373 の反応式
[CH:1]([CH:4]1[NH:8][CH2:7][C:6](=[O:9])[N:5]1[CH2:10][C:11]([O:13]CC)=O)([CH3:3])[CH3:2].[NH3:16]>CO>[CH:1]([CH:4]1[NH:8][CH2:7][C:6](=[O:9])[N:5]1[CH2:10][C:11]([NH2:16])=[O:13])([CH3:2])[CH3:3]

参加物

4

反応物 2

HCID 222AmmoniaHCID 14618022Ethyl 2-isopropyl-5-oxo-1-imidazolidineacetate

生成物 1

HCID 146180232-Isopropyl-5-oxo-1-imidazolidineacetamide

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

An ice cold solution of ethyl 2-isopropyl-5-oxo-1-imidazolidineacetate (3.8 g) in methanol (100 ml) was saturated with gaseous ammonia. The solution was stirred at room temperature overnight and the solvent was removed under reduced pressure yielding 2-isopropyl-5-oxo-1-imidazolidineacetamide as viscous oil (Rf 0.33; ethyl acetate/methanol 6:4, silica gel plates). Sulphate monohydrate salt, m.p. 64° C., resolidifing and final decomposition at 114°-118° C.

後処理

  1. customthe solvent was removed under reduced pressure

出典と根拠

ORDレコード
ord-08ada84eca774b0888130ad396cfd693
出典データセット
uspto-grants-1987_10
特許番号
US04703054

反応ノート

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