2-Benzyloxycarbonylmethyl-2-(pyrrol-1-yl)malonic acid diethyl ester → 2-Carboxymethyl-2-(pyrrol-1-yl)-malonic acid diethyl ester

HRID 256583

反応式

HRID 256583 の反応式
[CH2:1]([O:3][C:4](=[O:27])[C:5]([CH2:16][C:17]([O:19]CC1C=CC=CC=1)=[O:18])([N:11]1[CH:15]=[CH:14][CH:13]=[CH:12]1)[C:6]([O:8][CH2:9][CH3:10])=[O:7])[CH3:2]>O1CCOCC1.[C].[Pd]>[CH2:1]([O:3][C:4](=[O:27])[C:5]([CH2:16][C:17]([OH:19])=[O:18])([N:11]1[CH:12]=[CH:13][CH:14]=[CH:15]1)[C:6]([O:8][CH2:9][CH3:10])=[O:7])[CH3:2]

参加物

4

反応物 1

HCID 106193402-Benzyloxycarbonylmethyl-2-(pyrrol-1-yl)malonic acid diethyl ester

生成物 1

HCID 108029052-Carboxymethyl-2-(pyrrol-1-yl)-malonic acid diethyl ester収率 80.2%

試薬・触媒・溶媒 2

HCID 178418390HCID 178418390、化合物触媒HCID 312751,4-Dioxane溶媒

実験手順

A mixture of 2-benzyloxycarbonylmethyl-2-(pyrrol-1-yl)malonic acid diethyl ester (80.0 g) in dioxane (150 ml) was hydrogenated over 10% palladium-carbon (500 mg) at 40° C. After the calculated amount of hydrogen was absorbed, the catalyst was filtered off and the filtrate was evaporated under reduced pressure. The residue was recrystallized from ethyl acetate/n-hexane to give the title compound (48.7 g, 80.2%) as colorless crystals, mp 93°-94° C.

後処理

  1. customAfter the calculated amount of hydrogen was absorbed
  2. filtrationthe catalyst was filtered off
  3. customthe filtrate was evaporated under reduced pressure
  4. customThe residue was recrystallized from ethyl acetate/n-hexane

出典と根拠

ORDレコード
ord-aaf7310e824b4202a08add87a34cb156
出典データセット
uspto-grants-1993_11
特許番号
US05258382

関連ノート

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