Potassium Hydroxide → HCID 19785336、化合物
反応式
[S:1]1[CH:5]=[CH:4][CH:3]=[C:2]1[CH2:6][N:7]1[C:15]([NH:16][CH:17]2[CH2:22][CH2:21][N:20]([CH2:23][CH2:24][NH:25]C(=O)OCC)[CH2:19][CH2:18]2)=[N:14][C:13]2[C:8]1=[N:9][CH:10]=[N:11][CH:12]=2.[OH-].[K+]>CC(O)C>[NH2:25][CH2:24][CH2:23][N:20]1[CH2:19][CH2:18][CH:17]([NH:16][C:15]2[N:7]([CH2:6][C:2]3[S:1][CH:5]=[CH:4][CH:3]=3)[C:8]3[C:13]([N:14]=2)=[CH:12][N:11]=[CH:10][N:9]=3)[CH2:22][CH2:21]1参加物
4
実験手順
A mixture of 10 parts of ethyl [2-[4-[[9-(2-thienylmethyl)-9H-purin-8-yl]amino]-1-piperidinyl]ethyl]carbamate, 10 parts of potassium hydroxide and 240 parts of 2-propanol was stirred overnight at reflux temperature. The reaction mixture was evaporated. Water was added. After stirring, the product was filtered off and dried, yielding 3.6 parts (56%) of N-[1-(2-aminoethyl)-4-piperidinyl]-9-(2-thienylmethyl)-9H-purin-8-amine (compound 163).