Hydrochloric Acid → HCID 178468267、化合物

反応式

[C:1]([CH2:3][CH2:4][CH2:5][O:6][C@H:7]1[CH2:12][CH2:11][C@H:10]([N:13]([CH3:27])[S:14]([C:17]2[CH:22]=[CH:21][C:20]([C:23]([F:26])([F:25])[F:24])=[CH:19][CH:18]=2)(=[O:16])=[O:15])[CH2:9][CH2:8]1)#[N:2].Cl.[CH2:29]([OH:31])[CH3:30]>>[CH2:29]([O:31][C:1](=[NH:2])[CH2:3][CH2:4][CH2:5][O:6][C@H:7]1[CH2:8][CH2:9][C@H:10]([N:13]([CH3:27])[S:14]([C:17]2[CH:22]=[CH:21][C:20]([C:23]([F:24])([F:25])[F:26])=[CH:19][CH:18]=2)(=[O:16])=[O:15])[CH2:11][CH2:12]1)[CH3:30]

参加物

反応物 3

HCID 313Hydrochloric Acid

HCID 702Ethanol

HCID 178484853HCID 178484853、化合物

生成物 1

HCID 178468267HCID 178468267、化合物

実験手順

0.35 g (0.87 mmol) trans-N-[4-(3-Cyano-propoxy)-cyclohexyl]-N-methyl-4-trifluoromethyl-benzenesulfonamide in 6 ml ethanol were treated with HCl gas at low temperature for 20 min. The mixture was kept at −20° C. for 48 h, was concentrated under reduced pressure to yield 400 mg (quant.) trans-4-{4-[Methyl-(4-trifluoromethyl-benzenesulfonyl)-amino]-cyclohexyloxy}-butyrimidic acid ethyl ester as light brown oil, MS: 451 (MH+).

後処理

concentrationwas concentrated under reduced pressure

出典と根拠

ORDレコード: ord-d2a315993e7144a1a37f15d3138f58a0
出典データセット: uspto-grants-2005_02
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US06858651B2

反応ノート

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