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Sulfuric Acid → 2-(1-Adamantyl)-4-bromophenol
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Sulfuric Acid | HCID 1118 | — |
| 反応物 | 4-Bromophenol | HCID 7808 | — |
| 反応物 | 1-Adamantanol | HCID 64152 | — |
| 反応物 | Sodium Bicarbonate | HCID 516892 | — |
| 溶媒 | Water | HCID 962 | — |
| 溶媒 | Dichloromethane | HCID 6344 | — |
| 生成物 | 2-(1-Adamantyl)-4-bromophenol | HCID 4670494 | — |
反応手順
34.6 g (200 mmol) of p-bromophenol and 30.4 g (200 mmol) of 1 -adamantanol are dissolved in 100 ml of dichloromethane. To the resulting solution there are slowly added 10 ml of concentrated sulfuric acid. The mixture is stirred for 8 hours at ambient temperature poured into water, neutralized with sodium bicarbonate, extracted with methylene chloride, dried and evaporated. After recrystallization in isooctane 52.8 g of the expected product are obtained. Yield--86%. Melting point: 140°-141° C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | USRE034440 |
| 出典データセット | uspto-grants-1993_11 |
| ORD ID | ord-69f3d89a8ff740c5ab42f0fc4d0570ac |
| 出典メモ | uspto-grants-1993_11 |