1-Decanol → Decyl 2-Hydroxyoctanoate

HRID 256798

反応式

HRID 256798 の反応式
[OH:1][CH:2]([CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH3:11])[C:3]([OH:5])=[O:4].[CH2:12](O)[CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH3:21]>S(=O)(=O)(O)O>[OH:1][CH:2]([CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH3:11])[C:3]([O:5][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH3:21])=[O:4]

参加物

4

反応物 2

HCID 81741-DecanolHCID 94180Hydroxycaprylic Acid

生成物 1

HCID 18955021Decyl 2-Hydroxyoctanoate収率 77.3%

試薬・触媒・溶媒 1

HCID 1118Sulfuric Acid触媒

実験手順

A 250 ml one neck round bottom flask equipped with a Dean Stark trap, condenser and nitrogen inlet/outlet was charged with 20.0 g (0.125 moles) 2-hydroxyoctanoic acid, 79.0 g (0.499 moles) decyl alcohol, and 0.062 g sulfuric acid. The mixture was heated to 140° for 8 hours and water was collected as the reaction proceeded. The acid was neutralized by washing three times with 50 ml saturated sodium bicarbonate solution. Approximately 50 ml ether was needed to break the emulsion. The organic layer was collected and dried over magnesium sulfate. Excess decyl alcohol was removed by high vacuum distillation to yield 28.99 g (77.3% yield) of clear pale yellow liquid. According to GC the product is 99.6% pure.

後処理

  1. temperatureThe mixture was heated to 140° for 8 hours
  2. customwater was collected as the reaction
  3. washby washing three times with 50 ml saturated sodium bicarbonate solution
  4. customThe organic layer was collected
  5. dry with materialdried over magnesium sulfate
  6. customExcess decyl alcohol was removed by high vacuum distillation

出典と根拠

ORDレコード
ord-b00d648aea424b888fe4c5c262f9d621
出典データセット
uspto-grants-1993_11
特許番号
US05260051

関連ノート

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