2-Bromobenzo(b)thiophene → rac-[2-(Benzo[b]thiophen-2-yl)ethynyl]-3,4-dihydro-2,5,7,8-tetramethyl-2H-1-benzopyran-6-ol

HRID 256838

反応式

HRID 256838 の反応式
[C:1]([C:3]1([CH3:17])[CH2:8][CH2:7][C:6]2[C:9]([CH3:16])=[C:10]([OH:15])[C:11]([CH3:14])=[C:12]([CH3:13])[C:5]=2[O:4]1)#[CH:2].Br[C:19]1[S:23][C:22]2[CH:24]=[CH:25][CH:26]=[CH:27][C:21]=2[CH:20]=1>>[S:23]1[C:19]([C:2]#[C:1][C:3]2([CH3:17])[CH2:8][CH2:7][C:6]3[C:9]([CH3:16])=[C:10]([OH:15])[C:11]([CH3:14])=[C:12]([CH3:13])[C:5]=3[O:4]2)=[CH:20][C:21]2[CH:27]=[CH:26][CH:25]=[CH:24][C:22]1=2

参加物

3

反応物 2

HCID 947862-Bromobenzo(b)thiopheneHCID 14478563rac-3,4-dihydro-2-ethynyl-2,5,7,8-tetramethyl-2H-1-benzopyran-6ol

生成物 1

HCID 15171820rac-[2-(Benzo[b]thiophen-2-yl)ethynyl]-3,4-dihydro-2,5,7,8-tetramethyl-2H-1-benzopyran-6-ol

実験手順

Reaction of rac-3,4-dihydro-2-ethynyl-2,5,7,8-tetramethyl-2H-1-benzopyran-6-ol with 2-bromobenzo[b]thiophene under the conditions described in example 16 gave after chromatographic isolation and crystallization from ether/hexane colorless crystals with m.p. 120°-123° C.

後処理

  1. customgave
  2. customafter chromatographic isolation and crystallization from ether/hexane colorless crystals with m.p. 120°-123° C.

出典と根拠

ORDレコード
ord-a617309efa024efc821d88d8188e17b2
出典データセット
uspto-grants-1993_11
特許番号
US05260294

関連ノート

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