化工社化工社 化学情報印刷レポート · 研究参考用
Water → 3-(3-Cyclopropylmethoxy-1,2,5-thiadiazol-4-yl)pyridine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Water | HCID 962 | — |
| 反応物 | Sodium hydride | HCID 24758 | — |
| 反応物 | Cyclopropanemethanol | HCID 75644 | — |
| 反応物 | 3-Chloro-4-(pyridin-3-yl)-1,2,5-thiadiazole | HCID 10488164 | — |
| 溶媒 | Tetrahydrofuran | HCID 8028 | — |
| 生成物 | 3-(3-Cyclopropylmethoxy-1,2,5-thiadiazol-4-yl)pyridine | HCID 19075239 | 69% |
反応手順
To a solution of cyclopropylcarbinol (360 mg, 5 mmol) and sodium hydride (110 mg, 5 mmol) in dry tetrahydrofuran was added a solution of 3-(4-chloro-1,2,5-thiadiazol-3-yl)pyridine (490 mg, 2.5 mmol) in dry tetrahydrofuran. The reaction mixture was stirred at room temperature for 3 h. Water was added and the mixture was extracted with ether. The ether phase was dried and evaporated to yield 400 mg (69%) of the title compound.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05260311 |
| 出典データセット | uspto-grants-1993_11 |
| ORD ID | ord-e249e995ee78419f97922d0862449dde |
| 出典メモ | uspto-grants-1993_11 |