4-Bromo-3-methylaniline → N-([(4-bromo-3-methylphenyl)amino]carbonyl)-4-methylbenzenesulfonamide

HRID 257079

反応式

HRID 257079 の反応式
[Br:1][C:2]1[CH:8]=[CH:7][C:5]([NH2:6])=[CH:4][C:3]=1[CH3:9].[C:10]1([CH3:22])[CH:15]=[CH:14][C:13]([S:16]([N:19]=[C:20]=[O:21])(=[O:18])=[O:17])=[CH:12][CH:11]=1>C1(C)C=CC=CC=1.C(Cl)Cl>[Br:1][C:2]1[CH:8]=[CH:7][C:5]([NH:6][C:20]([NH:19][S:16]([C:13]2[CH:14]=[CH:15][C:10]([CH3:22])=[CH:11][CH:12]=2)(=[O:18])=[O:17])=[O:21])=[CH:4][C:3]=1[CH3:9]

参加物

5

反応物 2

HCID 233594-Bromo-3-methylanilineHCID 77703p-Toluenesulfonyl isocyanate

生成物 1

HCID 2375417N-([(4-bromo-3-methylphenyl)amino]carbonyl)-4-methylbenzenesulfonamide収率 80%

試薬・触媒・溶媒 2

HCID 1140Toluene溶媒2 回HCID 6344Dichloromethane溶媒2 回

実験手順

A solution of 5.58 g of 4-bromo-3-methyl-aniline in 20 ml of toluene and 5 ml of methylene chloride was added to a solution of 5.91 g of p-toluene-sulfonyl isocyanate in 50 ml of toluene and 10 ml of methylene chloride under a nitrogen atmosphere. The mixture was stirred overnight and filtered, providing 9.19 g of the title product, m.p. 178°-180° C.

後処理

  1. filtrationfiltered

出典と根拠

ORDレコード
ord-2b9c840527804147b86b4be65344d3b1
出典データセット
uspto-grants-1993_11
特許番号
US05260338

関連ノート

読み込み中…