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Thiazolidinedione → 5-(4-[2-(N-Methyl-N-(2-pyrimidinyl)amino)ethoxy]benzylidene)-2,4-thiazolidinedione
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Thiazolidinedione | HCID 5437 | — |
| 反応物 | Piperidinium acetate | HCID 3014295 | — |
| 反応物 | 4-[2-(N-Methyl-N-(2-pyrimidinyl)amino)ethoxy]-benzaldehyde | HCID 10038089 | — |
| 溶媒 | Toluene | HCID 1140 | — |
| 生成物 | 5-(4-[2-(N-Methyl-N-(2-pyrimidinyl)amino)ethoxy]benzylidene)-2,4-thiazolidinedione | HCID 54227469 | — |
反応手順
A solution of 4-[2-(N-methyl-N-(2-pyrimidinyl)amino) ethoxy]benzaldehyde (1.7 g) and 2,4-thiazolidinedione (0.7 g) in toluene (100 ml) containing a catalytic quantity of piperidinium acetate was boiled under reflux in a Dean and Stark apparatus for 2 hours. The mixture was cooled and filtered to give the title compound (mp 189°-90° C.).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05260445 |
| 出典データセット | uspto-grants-1993_11 |
| ORD ID | ord-bcdcd393a69142229c58293bb4bf9e26 |
| 出典メモ | uspto-grants-1993_11 |