HCID 19783098、化合物 → Ethyl 4-oxotetrahydro-2H-pyran-3-carboxylate

反応式

[CH2:1]([O:3][C:4]([C:6]1(F)[C:11](=[O:12])[CH2:10][CH2:9][O:8][CH2:7]1)=[O:5])[CH3:2].C(OC(C1(F)C(O)CCOC1)=O)C>>[CH2:1]([O:3][C:4]([CH:6]1[C:11](=[O:12])[CH2:10][CH2:9][O:8][CH2:7]1)=[O:5])[CH3:2]

参加物

反応物 2

HCID 19783098HCID 19783098、化合物

HCID 67884933Ethyl 3-fluoro-4-oxooxane-3-carboxylate

生成物 1

HCID 19783095Ethyl 4-oxotetrahydro-2H-pyran-3-carboxylate

実験手順

First, 3-ethoxycarbonyl-tetrahydro-4H-pyran4-one was synthesized referring the process described in Japan Laid-Open Patent Publication No. 32080/90. Then this ester was fluorinated in the same manner as in Example 4 to prepare 3-ethoxycarbony-3-fluoro-tetrahydro-4H-pyran-4-one which was then reduced in the same manner as in the same example to prepare 3-ethoxycarbonyl-3-fluoro-4-hydroxytetrahydro-4H-pyran.

出典と根拠

ORDレコード: ord-3bfa8bb644a84be8afedaf3d292605c9
出典データセット: uspto-grants-1993_11
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US05262385

反応ノート

読み込み中…

参加物