Isopropyl iodide → 2-Fluoro-4-isopropoxy-1-nitrobenzene

HRID 257376ノート

反応式

HRID 257376 の反応式
[F:1][C:2]1[CH:3]=[C:4]([OH:11])[CH:5]=[CH:6][C:7]=1[N+:8]([O-:10])=[O:9].I[CH:13]([CH3:15])[CH3:14].C(=O)([O-])[O-].[K+].[K+]>CC(C)=O>[CH:13]([O:11][C:4]1[CH:5]=[CH:6][C:7]([N+:8]([O-:10])=[O:9])=[C:2]([F:1])[CH:3]=1)([CH3:15])[CH3:14]

参加物

5

反応物 3

HCID 6362Isopropyl iodideHCID 11430Potassium CarbonateHCID 5209483-Fluoro-4-nitrophenol

生成物 1

HCID 135386522-Fluoro-4-isopropoxy-1-nitrobenzene収率 95.6%

試薬・触媒・溶媒 1

HCID 180Acetone溶媒

実験手順

By the method of Example 3, Step A, 23.15 g (0.147 mole) of 3-fluoro-4-nitrophenol and 29.92 g (0.175 mole) of 2-iodopropane were reacted in the presence of 20.73 g (0.150 mole) of anhydrous potassium carbonate in 450 mL of acetone, yielding 28.0 g of 4-isopropoxy-2-fluoronitrobenzene as an oil. The NMR was consistent with the proposed structure.

出典と根拠

ORDレコード
ord-dd66cd547acf42eab2d7601f2c383cc7
出典データセット
uspto-grants-1993_11
特許番号
US05262390

反応ノート

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