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Triethylamine → (R)-(+)-4-(1,1,1-trifluoro-2-octyloxycarbonyl)-4'-benzyloxybiphenyl
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Triethylamine | HCID 8471 | — |
| 反応物 | (R)-(+)-1,1,1-Trifluoro-2-octanol | HCID 2779099 | — |
| 反応物 | 2-Amino-3,4-dimethylpyridine | HCID 11007884 | — |
| 反応物 | 4'-(Phenylmethoxy)(1,1'-biphenyl)-4-carbonyl chloride | HCID 15084904 | — |
| 溶媒 | Dichloromethane | HCID 6344 | — |
| 生成物 | (R)-(+)-4-(1,1,1-trifluoro-2-octyloxycarbonyl)-4'-benzyloxybiphenyl | HCID 22848629 | — |
反応手順
To a solution of 4-benzyloxybiphenyl-4'-carboxylic acid chloride (1.23 g) in methylene chloride (10 ml) was added by little and little under ice-cooling a solution of (R)-(+)-1,1,1-trifluoro-2-octanol (0.96 g) ([α]D22.5 =+20.1, optical purity 96.3%ee), dimethyl-aminopyridine (0.55 g) and triethylamine (0.48 g) in methylene chloride (20 ml). The mixture was left to stand over-night at room temperature in order to complete the reaction before the mixture obtained was poured in ice-water.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05262086 |
| 出典データセット | uspto-grants-1993_11 |
| ORD ID | ord-b96a6fbc532b4d13b697817052cfd243 |
| 出典メモ | uspto-grants-1993_11 |