Imidazole → HCID 18953543、化合物

HRID 257416ノート

反応式

HRID 257416 の反応式
Cl[C:2]1[CH:7]=[CH:6][N:5]=[CH:4][C:3]=1[N+:8]([O-:10])=[O:9].[NH:11]1[CH:15]=[CH:14][N:13]=[CH:12]1.C(N(CC)CC)C>O1CCOCC1>[N:11]1([C:2]2[CH:7]=[CH:6][N:5]=[CH:4][C:3]=2[N+:8]([O-:10])=[O:9])[CH:15]=[CH:14][N:13]=[CH:12]1

参加物

5

反応物 3

HCID 795ImidazoleHCID 8471TriethylamineHCID 27357814-Chloro-3-nitropyridine

生成物 1

HCID 18953543HCID 18953543、化合物収率 96.4%

試薬・触媒・溶媒 1

HCID 312751,4-Dioxane溶媒

実験手順

4-Chloro-3-nitropyridine (2.00 g, 12.6 mmol) and imidazole (2.25 g, 33.0 mmol) were dissolved in 10 ml of 1,4-dioxane, and 2 ml of triethylamine was added thereto, followed by reaction at 90° to 100° C. for 1.5 hours. Then, the solvent was removed by distillation under reduced pressure, and the residue was purified by silica gel column chromatography [eluent: dichloromethane:methanol=10:1 (v/v)] to obtain 2.31 g of a yellow liquid (yield: 96.4%).

後処理

  1. customfollowed by reaction at 90° to 100° C. for 1.5 hours
  2. customThen, the solvent was removed by distillation under reduced pressure
  3. customthe residue was purified by silica gel column chromatography [eluent: dichloromethane:methanol=10:1 (v/v)]

出典と根拠

ORDレコード
ord-6adec537ab4744ba99ae6ece8f185091
出典データセット
uspto-grants-1993_11
特許番号
US05262415

反応ノート

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