N-methyl-5-nitropyridin-2-amine → N2-Methylpyridine-2,5-diamine
反応式
[N+:1]([C:4]1[CH:5]=[N:6][C:7]([NH:10][CH3:11])=[CH:8][CH:9]=1)([O-])=O.[H][H]>[Pt]=O.C(O)C>[NH2:1][C:4]1[CH:5]=[N:6][C:7]([NH:10][CH3:11])=[CH:8][CH:9]=1参加物
5
実験手順
To 40 ml of an ethanol solution of the methylamino compound (4 g) obtained in (a) described above was added, 400 mg of platinum oxide, followed by reaction in an atmosphere of hydrogen at room temperature for 15 hours. The solvent was thereafter removed by distallation, and the residue was purified by silica gel column chromatography (eluent: chloroform, and subsequently chloroform: methanol=20:1 (v/v)) to obtain 320 mg of the intended product as brown crystals.
後処理
- additionabove was added
- customThe solvent was thereafter removed by distallation
- customthe residue was purified by silica gel column chromatography (eluent
出典と根拠
- ORDレコード
- ord-7b2642a21e054599908b826ac8ef3952
- 出典データセット
- uspto-grants-1993_11
- 特許番号
- US05262415
反応ノート
読み込み中…