Pyridine, 4-ethyl-3-methyl- → 1-(3-Trifluoromethylphenyl)-4-(3-methyl-4-pyridyl)-pentane

HRID 257488

反応式

HRID 257488 の反応式
[CH3:1][C:2]1[CH:3]=[N:4][CH:5]=[CH:6][C:7]=1[CH2:8][CH3:9].Br[CH2:11][CH2:12][CH2:13][C:14]1[CH:19]=[CH:18][CH:17]=[C:16]([C:20]([F:23])([F:22])[F:21])[CH:15]=1>>[F:21][C:20]([F:23])([F:22])[C:16]1[CH:15]=[C:14]([CH2:13][CH2:12][CH2:11][CH:8]([C:7]2[CH:6]=[CH:5][N:4]=[CH:3][C:2]=2[CH3:1])[CH3:9])[CH:19]=[CH:18][CH:17]=1

参加物

3

反応物 2

HCID 34088Pyridine, 4-ethyl-3-methyl-HCID 197833671-(3-Bromopropyl)-3-(trifluoromethyl)benzene

生成物 1

HCID 148837961-(3-Trifluoromethylphenyl)-4-(3-methyl-4-pyridyl)-pentane収率 47.5%

実験手順

1.83 g (15.1 mmol) of 3-methyl-4-ethylpyridine and 4.03 g (15.1 mmol) of 1-bromo-3-(3-trifluoromethylphenyl)-propane were reacted in the same manner as in Example 26. The reaction product was purified to obtain 2.20 g of the desired compound (yield: 47.5%).

後処理

  1. customThe reaction product was purified

出典と根拠

ORDレコード
ord-79da715842cc4ed5a0a75cfeaac6dd4a
出典データセット
uspto-grants-1993_11
特許番号
US05262420

関連ノート

読み込み中…