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Hydrochloric Acid → 4-Benzoyl-2(S)-trifluoroacetamidobutyric acid
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Hydrochloric Acid | HCID 313 | — |
| 反応物 | Ethyl Acetate | HCID 8857 | — |
| 反応物 | N-[(3S)-2,6-dioxooxan-3-yl]-2,2,2-trifluoroacetamide | HCID 2779007 | — |
| 反応物 | Aluminum(III) Chloride | HCID 6451240 | — |
| 溶媒 | Benzene | HCID 241 | — |
| 生成物 | 4-Benzoyl-2(S)-trifluoroacetamidobutyric acid | HCID 14390810 | — |
反応手順
Heat at reflux for 3 hours a mixture of N-trifluoroacetyl-L-glutamic anhydride (18.0 g, 80 mmol) and AlCl3 (23.5 g, 177 mmol) in dry benzene (400 ml). Allow to cool, treat with ice (400 ml), conc. HCl (100 ml), and ethyl acetate (EtOAc) (400 ml). Dry the organic layer and concentrate to obtain the title compound as a brown crystalline solid (25 g).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05262436 |
| 出典データセット | uspto-grants-1993_11 |
| ORD ID | ord-46bd8a2309e340c792f0e0c9cc52a5c5 |
| 出典メモ | uspto-grants-1993_11 |