化工社化工社 化学情報印刷レポート · 研究参考用
m-ethylphenyl-N-methylcyanamide → N,N'-di-(m-ethylphenyl)-N-methylguanidine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | m-ethylphenyl-N-methylcyanamide | HCID 10103434 | — |
| 反応物 | m-Ethylaniline hydrochloride | HCID 21191493 | — |
| 溶媒 | Dichloromethane | HCID 6344 | — |
| 生成物 | N,N'-di-(m-ethylphenyl)-N-methylguanidine | HCID 178436394 | 56% |
反応手順
A mixture of N-(m-ethylphenyl)-N-methylcyanamide (640 mg, 4 mmol) and m-ethylaniline hydrochloride (630 mg, 4 mmol) was placed in a preheated oil bath at 160° C. for 2.5 hours and then allowed to cool to room temperature. The resulting solid was taken up in dichloromethane and washed with 10% NAOH solution. The organic layer concentrated and the residue was flash chromatographed on SiO2 to give N,N'-di-(m-ethylphenyl)-N-methylguanidine (630 mg, 56%) as a colorless liquid:
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05262568 |
| 出典データセット | uspto-grants-1993_11 |
| ORD ID | ord-23f092a4d4fd419bad7b04c2d1e3873d |
| 出典メモ | uspto-grants-1993_11 |