Dimethyldioxirane → 1-Hydroxy-2,6-diphenyl-3-methylpiperidin-4-yl Laurate
反応式
[C:1]([O:14][CH:15]1[CH2:20][CH:19]([C:21]2[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=2)[NH:18][CH:17]([C:27]2[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=2)[CH:16]1[CH3:33])(=[O:13])[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH3:12].CC1(C)O[O:36]1>>[C:1]([O:14][CH:15]1[CH2:20][CH:19]([C:21]2[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=2)[N:18]([OH:36])[CH:17]([C:27]2[CH:28]=[CH:29][CH:30]=[CH:31][CH:32]=2)[CH:16]1[CH3:33])(=[O:13])[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH3:12]参加物
3
実験手順
The general procedure of Example 2 is repeated using 11.5 g (25.5 mmol) of 2,6-diphenyl-3-methylpiperidin-4-yl laurate and 570 mL (25.5 mmol) of dimethyldioxirane (0.045M in acetone). 11.8 g (99% yield) of the title compound is isolated: mp 84°-91° C.
出典と根拠
- ORDレコード
- ord-bd28bc9a3f394ae3a460136e6323746f
- 出典データセット
- uspto-grants-1993_11
- 特許番号