Benzylamine → HCID 19781434、化合物

反応式

[CH2:1]([O:3][C:4](=[O:21])[CH:5]=[CH:6][CH2:7][CH2:8][C:9]1[C:17]2[C:12](=[CH:13][CH:14]=[CH:15][CH:16]=2)[N:11](C(=O)C)[CH:10]=1)[CH3:2].[CH2:22]([NH2:29])[C:23]1[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=1>>[CH2:1]([O:3][C:4](=[O:21])[CH2:5][CH:6]([CH2:7][CH2:8][C:9]1[C:17]2[C:12](=[CH:13][CH:14]=[CH:15][CH:16]=2)[NH:11][CH:10]=1)[NH:29][CH2:22][C:23]1[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=1)[CH3:2]

参加物

反応物 2

HCID 7504Benzylamine

HCID 53953280Ethyl 5-(1-acetyl-1H-indol-3-yl)pent-2-enoate

生成物 1

HCID 19781434HCID 19781434、化合物収率 79.9%

反応条件

温度: 80 °C

実験手順

A mixture of olefin 32 (5.0 g, 17.5 mmol) and benzylamine (7.7 mL, 70 mmol) was heated at 80° C. for 20 hours. The cooled reaction mixture was applied directly to a flash chromatography column (silica, 30% ethyl acetate/hexanes) to give the Micheal adduct 33 (4.9 g) as a viscous yellow oil.

後処理

customThe cooled reaction mixture

出典と根拠

ORDレコード: ord-ed2f5ef2241f4f2b9cb1f01ad77386a7
出典データセット: uspto-grants-1993_11
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US05264420

反応ノート

読み込み中…