Hydrochloric Acid → Ethyl valerimidate

HRID 257838

反応式

HRID 257838 の反応式
Cl.[C:2](=[NH:10])([O:7][CH2:8][CH3:9])[CH2:3][CH2:4][CH2:5][CH3:6].C(#N)CCCC.C(O)C.Cl>C(=O)([O-])[O-].[K+].[K+]>[C:2](=[NH:10])([O:7][CH2:8][CH3:9])[CH2:3][CH2:4][CH2:5][CH3:6]

参加物

6

反応物 4

HCID 313Hydrochloric AcidHCID 702EthanolHCID 8061ValeronitrileHCID 12283341Ethyl pentanimidate hydrochloride

生成物 1

HCID 12283340Ethyl valerimidate収率 72%

試薬・触媒・溶媒 1

HCID 11430Potassium Carbonate溶媒

実験手順

A 12.7 g (76.7 mmol) sample of ethyl valerimidate hydrochloride (prepared from valeronitrile, ethanol, and hydrogen chloride gas as described by A. J. Hill and I. Rabinowitz, J. Am. Chem. Soc., 1926, 48, 734) was dissolved in 33% (w/w) potassium carbonate solution (made by dissolving 15 g of K2CO3 in 30 mL of H2O) and immediately extracted with either (3×40 mL). The combined ether layers were dried over Na2SO4, filtered, and concentrated in vacuo to give 7.09 g (72%) of the product as a clear oil, which was used directly in the next step.

後処理

  1. extractionimmediately extracted with either (3×40 mL)
  2. dry with materialThe combined ether layers were dried over Na2SO4
  3. filtrationfiltered
  4. concentrationconcentrated in vacuo

出典と根拠

ORDレコード
ord-fc17f686422d4ef4b48fd012305b2431
出典データセット
uspto-grants-1993_11
特許番号
US05264439

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