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Sodium bis(trimethylsilyl)amide → 4-{1-[(2E)-but-2-en-1-yloxy]ethyl}-6-(2-methoxyphenyl)-2,2-dimethyl-1,2-dihydroquinoline
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Sodium bis(trimethylsilyl)amide | HCID 2724254 | — |
| 反応物 | 6-(2-Methoxyphenyl)-2,2-dimethyl-4-{1-[((E)-pent-2-enyl)oxy]ethyl}-1,2-dihydroquinoline 4-(1-Hydroxyethyl)-6-(2-methoxyphenyl)-2,2-dimethyl-2H-quinoline-1-carboxylic acid tert-butyl ester | HCID 69152453 | — |
| 溶媒 | Tetrahydrofuran | HCID 8028 | — |
| 溶媒 | 1-Bromo-pent-2-ene | HCID 140715 | — |
| 生成物 | 4-{1-[(2E)-but-2-en-1-yloxy]ethyl}-6-(2-methoxyphenyl)-2,2-dimethyl-1,2-dihydroquinoline | HCID 10316670 | 92.8% |
反応手順
6-(2-Methoxyphenyl)-2,2-dimethyl-4-{1-[((E)-pent-2-enyl)oxy]ethyl}-1,2-dihydroquinoline 4-(1-Hydroxyethyl)-6-(2-methoxyphenyl)-2,2-dimethyl-2H-quinoline-1-carboxylic acid tert-butyl ester (70 mg) was treated with 220 μL of 1 M solution of sodium bis(trimethylsilyl)amide in THF and 26 μL of 1-bromo-2-pentene to give the alkylated product, which was deprotected to yield 30 mg of the title compound as an oil.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06858627B2 |
| 出典データセット | uspto-grants-2005_02 |
| ORD ID | ord-7020842d333c4383854634d84e2c33f4 |
| 出典メモ | uspto-grants-2005_02 |