Potassium Hydroxide → 4-tert-Butylphenylacetylene

HRID 257988

反応式

HRID 257988 の反応式
C[Si]([C:5]#[C:6][C:7]1[CH:12]=[CH:11][C:10]([C:13]([CH3:16])([CH3:15])[CH3:14])=[CH:9][CH:8]=1)(C)C.[OH-].[K+]>C(O)(C)C>[C:13]([C:10]1[CH:9]=[CH:8][C:7]([C:6]#[CH:5])=[CH:12][CH:11]=1)([CH3:16])([CH3:15])[CH3:14]

参加物

4

反応物 2

HCID 14797Potassium HydroxideHCID 14989664((4-(tert-Butyl)phenyl)ethynyl)trimethylsilane2 回

生成物 1

HCID 27573024-tert-Butylphenylacetylene

試薬・触媒・溶媒 1

HCID 3776Isopropanol溶媒

実験手順

To a stirred solution of 1.44 g (6.23 mmol) of trimethylsilyl (4-tert-butyl) phenylethyne (Compound 21) in 5 ml of isopropanol was added 10 ml of 1N aqueous KOH and the mixture then stirred at room temperature for 6.5 hours. The isopropanol was removed under vacuum and the residue extracted with ether. The ether extract was washed with dilute HCl until the washings were acidic. The ether solution was then successively washed with water, saturated NaCl and NaHCO3 solutions and then dried (MGSO4). Solvent was then removed in-vacuo to give the title compound as a colorless oil. PMR (CDCl3): & 1.34 (9H, s), 3.05 (1H, s), 7.37 (2H, d, J~8.2 Hz), 7.46 (2H, d, J~8.2 Hz).

後処理

  1. customThe isopropanol was removed under vacuum
  2. extractionthe residue extracted with ether
  3. extractionThe ether extract
  4. washwas washed with dilute HCl until the washings
  5. washThe ether solution was then successively washed with water, saturated NaCl and NaHCO3 solutions
  6. customdried (MGSO4)
  7. customSolvent was then removed in-vacuo

出典と根拠

ORDレコード
ord-90a288469f7a47ab98bb7b39d840b463
出典データセット
uspto-grants-1993_11
特許番号
US05264456

関連ノート

読み込み中…