2-Phenylethanethiol → 6-(4-Methoxyphenyl)-2,2-dimethyl-4-phenethylsulfanylmethyl-1,2-dihydroquinoline

HRID 25808

反応式

HRID 25808 の反応式
[CH3:1][C:2]1([CH3:21])[CH:11]=[C:10]([CH3:12])[C:9]2[C:4](=[CH:5][CH:6]=[C:7](OS(C(F)(F)F)(=O)=O)[CH:8]=2)[NH:3]1.[CH3:22][O:23][C:24]1[CH:29]=[CH:28][C:27](B(O)O)=[CH:26][CH:25]=1.[C:33]1([CH2:39][CH2:40][SH:41])[CH:38]=[CH:37][CH:36]=[CH:35][CH:34]=1>>[CH3:22][O:23][C:24]1[CH:29]=[CH:28][C:27]([C:7]2[CH:8]=[C:9]3[C:4](=[CH:5][CH:6]=2)[NH:3][C:2]([CH3:1])([CH3:21])[CH:11]=[C:10]3[CH2:12][S:41][CH2:40][CH2:39][C:33]2[CH:38]=[CH:37][CH:36]=[CH:35][CH:34]=2)=[CH:26][CH:25]=1

参加物

4

反応物 3

HCID 781262-PhenylethanethiolHCID 201262(4-Methoxyphenyl)boronic acidHCID 20760320Trifluoromethanesulfonic acid 2,2,4-trimethyl-1,2-dihydroquinolin-6-yl ester

生成物 1

HCID 104096096-(4-Methoxyphenyl)-2,2-dimethyl-4-phenethylsulfanylmethyl-1,2-dihydroquinoline

実験手順

Trifluoromethanesulfonic acid 2,2,4-trimethyl-1,2-dihydroquinolin-6-yl ester was coupled with 4-methoxyphenylboronic acid. Bromination and coupling reaction with 2-phenylethanethiol gave 15 mg of the title compound.

出典と根拠

ORDレコード
ord-76ddf474d34a452a8fdcc9fc59869736
出典データセット
uspto-grants-2005_02
特許番号
US06858627B2

関連ノート

読み込み中…