Bromine → Methyl 4-bromo-7-methoxy-2H-1,3-benzodioxole-5-carboxylate
反応式
[CH3:1][O:2][C:3]1[C:4]2[O:15][CH2:14][O:13][C:5]=2[CH:6]=[C:7]([CH:12]=1)[C:8]([O:10][CH3:11])=[O:9].[Br:16]Br>C(O)(=O)C>[Br:16][C:6]1[C:5]2[O:13][CH2:14][O:15][C:4]=2[C:3]([O:2][CH3:1])=[CH:12][C:7]=1[C:8]([O:10][CH3:11])=[O:9]参加物
4
実験手順
In 35 ml of acetic acid was dissolved 10.5 g of methyl 5-methoxy-3,4-methylenedioxybenzoate, and a solution of bromine (formed by diluting 8 g of bromine with 25 ml of acetic acid) was dropped into the solution over a period of 1 hour. The mixture was stirred at room temperature for 10 hours and the reaction liquid was poured into ice water, and the formed precipitate was recovered by filtration and recrystallized from ethanol to obtain methyl 2-bromo-5-methoxy-3,4-methylenedioxybenzoate (the yield was 51%).
後処理
- customthe reaction liquid
- filtrationthe formed precipitate was recovered by filtration
- customrecrystallized from ethanol
出典と根拠
- ORDレコード
- ord-721af72956c94556ae745bc4f58863fa
- 出典データセット
- uspto-grants-1993_11
- 特許番号
- US05264594
反応ノート
読み込み中…