2-Phenylethanethiol → 6-(5-Isopropyl-2-methoxyphenyl)-2,2-dimethyl-4-phenethylsulfanylmethyl-1,2-dihydroquinoline

HRID 25816

反応式

HRID 25816 の反応式
[CH3:1][C:2]1([CH3:21])[CH:11]=[C:10]([CH3:12])[C:9]2[C:4](=[CH:5][CH:6]=[C:7](OS(C(F)(F)F)(=O)=O)[CH:8]=2)[NH:3]1.[CH:22]([C:25]1[CH:26]=[CH:27][C:28]([O:34][CH3:35])=[C:29](B(O)O)[CH:30]=1)([CH3:24])[CH3:23].[C:36]1([CH2:42][CH2:43][SH:44])[CH:41]=[CH:40][CH:39]=[CH:38][CH:37]=1>>[CH:22]([C:25]1[CH:26]=[CH:27][C:28]([O:34][CH3:35])=[C:29]([C:7]2[CH:8]=[C:9]3[C:4](=[CH:5][CH:6]=2)[NH:3][C:2]([CH3:1])([CH3:21])[CH:11]=[C:10]3[CH2:12][S:44][CH2:43][CH2:42][C:36]2[CH:41]=[CH:40][CH:39]=[CH:38][CH:37]=2)[CH:30]=1)([CH3:24])[CH3:23]

参加物

4

反応物 3

HCID 781262-PhenylethanethiolHCID 45891905-Isopropyl-2-methoxyphenylboronic acidHCID 20760320Trifluoromethanesulfonic acid 2,2,4-trimethyl-1,2-dihydroquinolin-6-yl ester

生成物 1

HCID 100042906-(5-Isopropyl-2-methoxyphenyl)-2,2-dimethyl-4-phenethylsulfanylmethyl-1,2-dihydroquinoline

実験手順

Trifluoromethanesulfonic acid 2,2,4-trimethyl-1,2-dihydroquinolin-6-yl ester was coupled with 5-isopropyl-2-methoxyphenylboronic acid. Bromination and coupling reaction with 2-phenylethanethiol gave 30 mg of the title compound.

出典と根拠

ORDレコード
ord-4175792f7f1046e493a98b8019fb87d9
出典データセット
uspto-grants-2005_02
特許番号
US06858627B2

関連ノート

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