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Allyl Mercaptan → 4-Allylsulfanylmethyl-6-(2-nitrophenyl)-2,2-dimethyl-1,2-dihydroquinoline
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Allyl Mercaptan | HCID 13367 | — |
| 反応物 | N-bromobutanimide | HCID 67184 | — |
| 反応物 | (2-Nitrophenyl)boronic acid | HCID 2773548 | — |
| 反応物 | 6-Bromo-2,2,4-trimethyl-1,2-dihydroquinoline | HCID 10729464 | — |
| 反応物 | Trifluoromethanesulfonic acid 2,2,4-trimethyl-1,2-dihydroquinolin-6-yl ester | HCID 20760320 | — |
| 生成物 | 4-Allylsulfanylmethyl-6-(2-nitrophenyl)-2,2-dimethyl-1,2-dihydroquinoline | HCID 10021826 | — |
反応手順
6-Bromo-2,2,4-trimethyl-1,2-dihydroquinoline was coupled with 2-nitrophenylboronic acid using the procedure described in Example 7 for trifluoromethanesulfonic acid 2,2,4-trimethyl-1,2-dihydroquinolin-6-yl ester. The resulting intermediate was brominated with NBS, followed by the coupling reaction with allyl mercaptan as described in Example 7, to provide 15 mg of the title compound as an oil.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06858627B2 |
| 出典データセット | uspto-grants-2005_02 |
| ORD ID | ord-620b59c3289f49d2a64264d11b6dd951 |
| 出典メモ | uspto-grants-2005_02 |