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Potassium Phosphate, Tribasic → 6-(2,3-Dimethoxyphenyl)-2,2,4-trimethyl-1,2-dihydroquinoline
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Potassium Phosphate, Tribasic | HCID 62657 | — |
| 反応物 | 2,3-Dimethoxybenzeneboronic acid | HCID 5156491 | — |
| 反応物 | 6-Bromo-2,2,4-trimethyl-1,2-dihydroquinoline | HCID 10729464 | — |
| 触媒 | Bis(cyclopenta-1,4-dien-1-yl(diphenyl)phosphane);dichloropalladium;iron(2+) | HCID 178418228 | — |
| 溶媒 | Dimethyl Sulfoxide | HCID 679 | — |
| 生成物 | 6-(2,3-Dimethoxyphenyl)-2,2,4-trimethyl-1,2-dihydroquinoline | HCID 22566517 | 61% |
反応手順
6-Bromo-2,2,4-trimethyl-1,2-dihydroquinoline (256 mg, 1.02 mmol) (Example 8) and 2,3-dimethoxyphenyl boronic acid (370 mg, 2.03 mmol) were combined in DMSO (2 mL). 2 M K3PO4 (1 mL) was added, followed by PdCl2(dppf) (50 mg). The contents were placed in a microwave reaction vessel assembly and irradiated at 120° C. for 15 minutes. The reaction was cooled to room temperature. Purification of the crude product by chromatography afforded 6-(2,3-dimethoxyphenyl)-2,2,4-trimethyl-1,2-dihydroquinoline (190 mg, 61%) as a white solid.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06858627B2 |
| 出典データセット | uspto-grants-2005_02 |
| ORD ID | ord-7b25775c45f94861956773193f671d73 |
| 出典メモ | uspto-grants-2005_02 |