2-Chloro-1-(2,5-dimethoxyphenyl)ethanone → 2-Chloro-1-(3,4-dimethoxyphenyl)ethan-1-ol
反応式
ClCC(C1C=C(OC)C=CC=1OC)=O.[Cl:15][CH2:16][C:17]([C:19]1[CH:24]=[CH:23][C:22]([O:25][CH3:26])=[C:21]([O:27][CH3:28])[CH:20]=1)=[O:18].ClCC(C1C=C(OC)C=CC=1OC)O>>[Cl:15][CH2:16][CH:17]([C:19]1[CH:24]=[CH:23][C:22]([O:25][CH3:26])=[C:21]([O:27][CH3:28])[CH:20]=1)[OH:18]参加物
4
実験手順
Cultivation, reaction and purification were carried out in the same way as described in Example 9 except that 2-chloro-1-(2',5'-dimethoxyphenyl) ethanone, 2-chloro-1-(3',4'-dimethoxyphenyl) ethanone were used as substrate and (-)-2-chloro-1-(2',5'-dimethoxyphenyl) ethanol, (-)-2-chloro-1-(3',4'-dimethoxyphenyl) ethanol were obtained. The yield, specific rotation and optical purity determined by high-performance liquid chromatography were shown in Table 10.