Benzoyl chloride → HCID 20095459、化合物

HRID 258271ノート

反応式

HRID 258271 の反応式
[CH3:1][NH:2][CH2:3][C:4]1[CH:9]=[CH:8][C:7]([S:10][CH3:11])=[CH:6][CH:5]=1.C(=O)([O-])[O-].[K+].[K+].[C:18](Cl)(=[O:25])[C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1>CC(C)=O.O>[C:18]([N:2]([CH3:1])[CH2:3][C:4]1[CH:9]=[CH:8][C:7]([S:10][CH3:11])=[CH:6][CH:5]=1)(=[O:25])[C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1

参加物

6

反応物 3

HCID 7412Benzoyl chlorideHCID 11430Potassium CarbonateHCID 2452234N-Methyl-1-[4-(methylsulfanyl)phenyl]methanamine

生成物 1

HCID 20095459HCID 20095459、化合物

試薬・触媒・溶媒 2

HCID 180Acetone溶媒HCID 962Water溶媒2 回

実験手順

N-Methyl-N-(4-methylthiobenzyl)amine (4.2 g) and potassium carbonate (5.2 g) are dissolved in a mixture of acetone (20 ml) and water (20 ml), and thereto is added dropwise benzoyl chloride (3.7 ml) gradually under ice cooling. After the mixture is stirred at the same temperature for 30 minutes, the reacting mixture is poured into water, and then extracted with dichloromethane. The extract is washed with aqueous sodium chloride solution, and dried over magnesium sulfate. Dichloromethane is distilled off to give N-benzoyl-N-methyl-N-(4-methylthiobenzyl)amine (6.8 g).

後処理

  1. extractionextracted with dichloromethane
  2. washThe extract is washed with aqueous sodium chloride solution
  3. dry with materialdried over magnesium sulfate
  4. distillationDichloromethane is distilled off

出典と根拠

ORDレコード
ord-502244294e5a4e7c8a95412a211f98f5
出典データセット
uspto-grants-1993_11
特許番号
US05266577

反応ノート

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