Hydrochloric Acid → 128668-80-4

HRID 258273ノート

反応式

HRID 258273 の反応式
C(O)C.Cl.[C:5]([N:13](C)[CH2:14][C:15]1[CH:20]=[CH:19][C:18]([S:21]([CH3:23])=[O:22])=[CH:17][CH:16]=1)(=O)C1C=CC=CC=1>O>[CH3:5][NH:13][CH2:14][C:15]1[CH:20]=[CH:19][C:18]([S:21]([CH3:23])=[O:22])=[CH:17][CH:16]=1

参加物

5

反応物 3

HCID 313Hydrochloric AcidHCID 702EthanolHCID 20095449HCID 20095449、化合物

生成物 1

HCID 12153283128668-80-4収率 84.1%

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

To a mixture of ethanol (40 ml), water (20 ml) and conc. hydrochloric acid (60 ml), N-benzoyl-N-methyl-N-(4-methylsulfinylbenzyl)amine (4.1 g) is added and the mixture is heated with refluxing for 12 hours. After the reaction, the solvent is distilled off under reduced pressure, and to the resulting residue is added 20 % aqueous sodium hydroxide solution, and the mixture is extracted with diethyl ether. The extract is washed successively with water and aqueous sodium chloride solution, and dried over magnesium sulfate. Diethyl ether is distilled off to give N-methyl-N-(4-methylsulfinylbenzyl)amine (2.2 g).

後処理

  1. additionis added
  2. temperaturethe mixture is heated
  3. temperaturewith refluxing for 12 hours
  4. customAfter the reaction
  5. distillationthe solvent is distilled off under reduced pressure
  6. additionto the resulting residue is added 20 % aqueous sodium hydroxide solution
  7. extractionthe mixture is extracted with diethyl ether
  8. washThe extract is washed successively with water and aqueous sodium chloride solution
  9. dry with materialdried over magnesium sulfate
  10. distillationDiethyl ether is distilled off

出典と根拠

ORDレコード
ord-eab1dbedc751470d9a26814da6701750
出典データセット
uspto-grants-1993_11
特許番号
US05266577

反応ノート

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