化工社化工社 化学情報印刷レポート · 研究参考用
2-Chlorothiophene → Methanone, (5-chloro-2-thienyl)phenyl-
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 2-Chlorothiophene | HCID 7299 | — |
| 反応物 | 4-tert-Butylphenol | HCID 7393 | — |
| 反応物 | Benzoyl chloride | HCID 7412 | — |
| 生成物 | Methanone, (5-chloro-2-thienyl)phenyl- | HCID 901505 | — |
| 生成物 | 2-Benzoyl-5-(4-t-butyl-phenoxy)thiophene | HCID 19935313 | — |
反応手順
2-benzoyl-5-chlorothiophene was synthesized via Friedel-Crafts acylation of benzoyl chloride with 2-chlorothiophene. This was reacted under standard conditions with 4-t-butyl phenol to produce 2-benzoyl-5-(4-t-butyl-phenoxy)thiophene. It was discovered by thin layer chromatography that the displacement of the acyl chlorine proceeds completely with no side reactions. Complete nucleophilic displacement demonstrates that this reaction meets the requirements necessary for high polymer formation via a step growth reaction.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05266677 |
| 出典データセット | uspto-grants-1993_11 |
| ORD ID | ord-7d9395336f5a4b8f89e6c8b95260e3f4 |
| 出典メモ | uspto-grants-1993_11 |