Dichloromethane → 1,2-Dimethoxy-4-(2-propenyl)-5-(2-cyano-3-methoxy-2-propenyl)benzene

HRID 258559

反応式

HRID 258559 の反応式
[CH3:1][O:2][C:3]1[CH:4]=[CH:5][C:6]([CH2:11][CH:12]=[CH2:13])=[CH:7][C:8]=1[O:9][CH3:10].CO[CH:16]([O:21][CH3:22])[C:17](=[CH2:20])[C:18]#[N:19].C(Cl)Cl>CCOCC>[CH3:1][O:2][C:3]1[CH:4]=[C:5]([CH2:20][C:17]([C:18]#[N:19])=[CH:16][O:21][CH3:22])[C:6]([CH2:11][CH:12]=[CH2:13])=[CH:7][C:8]=1[O:9][CH3:10]

参加物

5

反応物 3

HCID 6344DichloromethaneHCID 7127MethyleugenolHCID 124234392-Dimethoxymethylacrylonitrile

生成物 1

HCID 544449171,2-Dimethoxy-4-(2-propenyl)-5-(2-cyano-3-methoxy-2-propenyl)benzene

試薬・触媒・溶媒 1

HCID 3283Diethyl Ether溶媒

実験手順

To a solution of 10 g. of methyl eugenol and 8.1 g. of 2-dimethoxymethylacrylonitrile in 200 ml. of dry methylene chloride was added 1.97 ml. of stannic chloride. After stirring for 5 hours at room temperature, 300 ml. of ether was added and the mixture washed with a 5% sodium bicarbonate solution (until basic). The organic layer was dried (MgSO4) and the solvent removed under reduced pressure. The residue was triturated with ether to give 1,2-dimethoxy-4-(2-propenyl)-5-(2-cyano-3-methoxy-2-propenyl)benzene, m.p. 77°-79°.

後処理

  1. washthe mixture washed with a 5% sodium bicarbonate solution (until basic)
  2. dry with materialThe organic layer was dried (MgSO4)
  3. customthe solvent removed under reduced pressure
  4. customThe residue was triturated with ether

出典と根拠

ORDレコード
ord-b285d52060e248b7bf3f7ddf301c25ec
出典データセット
uspto-grants-1977_07
特許番号
US04033962

関連ノート

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