Piperidine → HCID 20365141、化合物

HRID 258573ノート

反応式

HRID 258573 の反応式
[CH2:1]1[C:9]2[C:4](=[CH:5][C:6]([CH2:10][CH2:11][CH2:12]Br)=[CH:7][CH:8]=2)[CH2:3][CH2:2]1.[NH:14]1[CH2:19][CH2:18][CH2:17][CH2:16][CH2:15]1>C1(C)C=CC=CC=1.CCOCC>[CH2:1]1[C:9]2[C:4](=[CH:5][C:6]([CH2:10][CH2:11][CH2:12][N:14]3[CH2:19][CH2:18][CH2:17][CH2:16][CH2:15]3)=[CH:7][CH:8]=2)[CH2:3][CH2:2]1

参加物

5

反応物 2

HCID 8082PiperidineHCID 126461775-(3-Bromopropyl)-2,3-dihydro-1H-indene

生成物 1

HCID 20365141HCID 20365141、化合物

試薬・触媒・溶媒 2

HCID 1140Toluene溶媒HCID 3283Diethyl Ether溶媒

実験手順

The crude 3-(5-Indanyl)-1-bromopropane (13.0 g, 0.054 M) is dissolved in 200 ml toluene and treated with 50 g of piperidine. The mixture is heated under reflux overnight, then cooled and diluted with ether to precipitate salts. The salts are removed by filtration and the solvent removed from the filtrate in vacuo. The residue is distilled collecting 8.4 g (64%) of desired product boiling at 135°-140° (0.15 mm).

後処理

  1. temperatureThe mixture is heated
  2. temperatureunder reflux overnight
  3. temperaturecooled
  4. customto precipitate salts
  5. customThe salts are removed by filtration
  6. customthe solvent removed from the filtrate in vacuo
  7. distillationThe residue is distilled
  8. customcollecting 8.4 g (64%) of desired product boiling at 135°-140° (0.15 mm)

出典と根拠

ORDレコード
ord-ecf5ce9540a94059a23b52bb29e84cd8
出典データセット
uspto-grants-1977_07
特許番号
US04033971

反応ノート

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