化工社化工社 化学情報印刷レポート · 研究参考用
Water → 2-Phenyl-4-(beta-hydroxyethyl)thiazole
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Water | HCID 962 | — |
| 反応物 | Ethyl 2-(2-phenyl-1,3-thiazol-4-yl)acetate | HCID 2797666 | — |
| 反応物 | Aluminium lithium hydride | HCID 21226445 | — |
| 溶媒 | Tetrahydrofuran | HCID 8028 | — |
| 生成物 | 2-Phenyl-4-(beta-hydroxyethyl)thiazole | HCID 10608315 | — |
反応手順
Reduction of the latter ester to the title compound is effected as follows: The ester (159 g) is dissolved in dry tetrahydrofuran (250 ml) and added dropwise during 30 min to a stirred mixture of lithium aluminum hydride (50 g) in tetrahydrofuran. The mixture is stirred for one hour, cooled and water (150 ml) is slowly added. The mixture is dried over magnesium sulfate and evaporated to give the title compound as a yellow oil, γmaxCHCl3 3610, 3420 and 1520 cm- 1.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04033977 |
| 出典データセット | uspto-grants-1977_07 |
| ORD ID | ord-5f3d911fa4f342a987c166e3d11b4fc7 |
| 出典メモ | uspto-grants-1977_07 |