4-Methoxy-2-quinolinecarboxylic acid → HCID 178492678、化合物

HRID 258669

反応式

HRID 258669 の反応式
[CH3:1][O:2][C:3]1[C:15]2[C:10](=[CH:11][CH:12]=[CH:13][CH:14]=2)[N:9]=[C:5]([C:6](O)=[O:7])[CH:4]=1.[NH2:16][C:17]1[NH:21][N:20]=[N:19][N:18]=1>CN(C)C=O>[CH3:1][O:2][C:3]1[C:15]2[C:10](=[CH:11][CH:12]=[CH:13][CH:14]=2)[N:9]=[C:5]([C:6]([NH:16][C:17]2[NH:21][N:20]=[N:19][N:18]=2)=[O:7])[CH:4]=1

参加物

4

反応物 2

HCID 5945964-Methoxy-2-quinolinecarboxylic acidHCID 178509299HCID 178509299、化合物

生成物 1

HCID 178492678HCID 178492678、化合物

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

実験手順

4-Methoxyquinaldic acid (7.25 g) was dissolved in dry dimethylformamide (20 ml). N,N'-carbonyldiimidazole (5.8 g) was added, and the solution was stirred for 6 hours at room temperature. 5-Aminotetrazole (3.69 g) was added and the mixture was stirred overnight at room temperature. The solid was filtered off, washed with methanol and dissolved in dimethylformamide (50 ml) with the minimum addition of dimethylaminoethanol to effect dissolution. Water (50 ml) was added, and the solution was adjusted to pH 2 by the addition of aqueous hydrochloric acid. The solid was filtered off to give 4-methoxy-N(1H-tetrazol- 5-yl)quinaldamide, m.p. 289° (d).

後処理

  1. stirringthe mixture was stirred overnight at room temperature
  2. filtrationThe solid was filtered off
  3. washwashed with methanol
  4. dissolutiondissolved in dimethylformamide (50 ml) with the minimum addition of dimethylaminoethanol
  5. dissolutiondissolution
  6. additionWater (50 ml) was added
  7. additionthe solution was adjusted to pH 2 by the addition of aqueous hydrochloric acid
  8. filtrationThe solid was filtered off

出典と根拠

ORDレコード
ord-71265ad2affa449288b009151d4ae194
出典データセット
uspto-grants-1977_07
特許番号
US04034075

関連ノート

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