N,N-Bis(2-hydroxyethyl)ethylenediamine → 1,1-dioctadecyl-3-{2-[Bis(2-Hydroxyethyl)Amino]Ethyl}Urea

HRID 258730ノート

反応式

HRID 258730 の反応式
[CH2:1]([N:19]([CH2:23][CH2:24][CH2:25][CH2:26][CH2:27][CH2:28][CH2:29][CH2:30][CH2:31][CH2:32][CH2:33][CH2:34][CH2:35][CH2:36][CH2:37][CH2:38][CH2:39][CH3:40])[C:20](Cl)=[O:21])[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH3:18].[OH:41][CH2:42][CH2:43][N:44]([CH2:48][CH2:49][OH:50])[CH2:45][CH2:46][NH2:47]>C1C=CC=CC=1>[CH2:1]([N:19]([CH2:23][CH2:24][CH2:25][CH2:26][CH2:27][CH2:28][CH2:29][CH2:30][CH2:31][CH2:32][CH2:33][CH2:34][CH2:35][CH2:36][CH2:37][CH2:38][CH2:39][CH3:40])[C:20]([NH:47][CH2:46][CH2:45][N:44]([CH2:48][CH2:49][OH:50])[CH2:43][CH2:42][OH:41])=[O:21])[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH3:18]

参加物

4

反応物 2

HCID 98535N,N-Bis(2-hydroxyethyl)ethylenediamineHCID 3016265N,N-dioctadecylcarbamoyl chloride

生成物 1

HCID 204330001,1-dioctadecyl-3-{2-[Bis(2-Hydroxyethyl)Amino]Ethyl}Urea収率 95.5%

試薬・触媒・溶媒 1

HCID 241Benzene溶媒

実験手順

A mixture of N,N-dioctadecylcarbamyl chloride (2.9 g.), N,N-bis(2-hydroxyethyl)-1,2-ethanediamine (4.0 g.) and benzene (50 ml.) is refluxed and stirred for three hours. The mixture is then cooled, concentrated in vacuo and the residue taken up on chloroform (100 ml.). The chloroform solution is washed successively with water (2× 50 ml.), aqueous sodium hydroxide (1× 50 ml. of 1 N) and water (2× 50 ml.), then dried (Na2SO4). Removal of the chloroform in vacuo leaves the crude product as an oil (3.3 g.).

後処理

  1. temperatureis refluxed
  2. temperatureThe mixture is then cooled
  3. concentrationconcentrated in vacuo
  4. washThe chloroform solution is washed successively with water (2× 50 ml.), aqueous sodium hydroxide (1× 50 ml. of 1 N) and water (2× 50 ml.)
  5. dry with materialdried (Na2SO4)
  6. customRemoval of the chloroform in vacuo

出典と根拠

ORDレコード
ord-323f327d57064703ac2a5c4a1f4c030a
出典データセット
uspto-grants-1977_07
特許番号
US04034040

反応ノート

読み込み中…