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4-Ethoxybenzaldehyde → 3-(4-Ethoxycinnamoyl)-7-methoxycoumarin
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 4-Ethoxybenzaldehyde | HCID 24834 | — |
| 反応物 | 3-Acetyl-7-methoxycoumarin | HCID 2054475 | — |
| 触媒 | Piperidine | HCID 8082 | — |
| 溶媒 | Acetonitrile | HCID 6342 | — |
| 生成物 | 3-(4-Ethoxycinnamoyl)-7-methoxycoumarin | HCID 54114618 | — |
反応手順
A suspension of 2.18 g 3-acetyl-7-methoxycoumarin and 1.65 g p-ethoxybenzaldehyde in 100 ml alcohol was heated under reflux on a steam bath. Acetonitrile was added until solution was attained. Fifty drops of piperidine were added and the reaction mixture heated under reflux for 90 minutes. An additional fifty drops of piperidine were added and the solution was heated under reflux another hour. The product separated upon cooling and was washed with alcohol before being recrystallized from a mixture of alcohol and acetonitrile.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04147552 |
| 出典データセット | uspto-grants-1979_04 |
| ORD ID | ord-943fff4c598841fc8e0531cb49187a38 |
| 出典メモ | uspto-grants-1979_04 |