関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Hydrazine Sulfate | HCID 24842 | — |
| 反応物 | Potassium Bicarbonate | HCID 516893 | — |
| 反応物 | HCID 178485010 | HCID 178485010 | — |
| 溶媒 | Dimethylformamide | HCID 6228 | — |
| 生成物 | HCID 178485006 | HCID 178485006 | 46.9% |
反応手順
A mixture of the isothiourea dihydrochloride from Example 1 (i) (8.3 g), hydrazine sulphate (4.1 g), potassium hydrogen carbonate (12.5 g) and anhydrous dimethyl formamide (100 ml) was stirred at 90° C. for 3 hours. Following cooling and filtration from inorganic material, the filtrate containing the free base was treated with ethanolic hydrogen chloride. The residue was then triturated with isopropanol to give a solid which was recrystallised from aqueous isopropanol to give the title compound (1.94 g), m.p. 234°-235°.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US04034101 |
|---|
| 出典データセット | uspto-grants-1977_07 |
|---|
| ORD ID | ord-2179ab7713b242788365fa0853126697 |
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| 出典メモ | uspto-grants-1977_07 |
|---|
