Hydrochloric Acid → N-Methyl-N'-methylamino-N"-[2-((4-methyl-5-imidazolyl)methylthio)ethyl]guanidine dihydrochloride

HRID 258745

反応式

HRID 258745 の反応式
[ClH:1].Cl.O[NH:4][C:5]([NH:17][CH3:18])=[N:6][CH2:7][CH2:8][S:9][CH2:10][C:11]1[NH:15][CH:14]=[N:13][C:12]=1[CH3:16].S(O)(O)(=O)=O.[CH3:24][N:25](C(OC(C)(C)C)=O)N.C(=O)([O-])O.[K+].Cl>CN(C)C=O>[ClH:1].[ClH:1].[CH3:18][NH:17][C:5]([NH:4][NH:25][CH3:24])=[N:6][CH2:7][CH2:8][S:9][CH2:10][C:11]1[NH:15][CH:14]=[N:13][C:12]=1[CH3:16]

参加物

6

反応物 4

HCID 313Hydrochloric AcidHCID 516893Potassium BicarbonateHCID 88794812N-methyl-N-tert-butoxycarbonylhydrazine sulphateHCID 178485010HCID 178485010、化合物

生成物 1

HCID 178486240N-Methyl-N'-methylamino-N"-[2-((4-methyl-5-imidazolyl)methylthio)ethyl]guanidine dihydrochloride

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

反応条件

温度
90 °C

実験手順

A mixture of the isothiourea dihydrochloride of Example 1 (i) (6.7 g), N-methyl-N-tert-butoxycarbonylhydrazine sulphate (5.7 g), potassium hydrogen carbonate (10.0 g) and anhydrous dimethylformamide (80 ml) was stirred at 90° C. for 3 hours. After cooling, filtration and concentration to yield the free base, this was heated under reflux with ethanolic hydrogen chloride. Concentration and trituration of the residual product yielded the title compound.

後処理

  1. temperatureAfter cooling
  2. filtrationfiltration and concentration
  3. customto yield the free base
  4. temperaturethis was heated
  5. concentrationConcentration and trituration of the residual product

出典と根拠

ORDレコード
ord-ae33860c3be94f0fa9214fab10a9ef6e
出典データセット
uspto-grants-1977_07
特許番号
US04034101

関連ノート

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