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Dimethyl 3-oxoglutarate → Methyl 3-[7-(diethylamino)-2-oxo-2h-chromen-3-yl]-3-oxopropanoate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Dimethyl 3-oxoglutarate | HCID 74591 | — |
| 反応物 | 4-(Diethylamino)-2-hydroxybenzaldehyde | HCID 87293 | — |
| 生成物 | Methyl 3-[7-(diethylamino)-2-oxo-2h-chromen-3-yl]-3-oxopropanoate | HCID 3326307 | — |
反応手順
A solution of 1.93 g 4-diethylaminosalicylaldehyde, 1.80 g. dimethyl 1,3-acetone dicarboxylate in 10 ml. alcohol containing 10 drops piperidine was heated under reflux on a steam bath for 2 hours. After chilling in the freezer, the product was collected and recrystallized from a mixture of alcohol and acetonitrile. Yield 2.6 g (82%).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04147552 |
| 出典データセット | uspto-grants-1979_04 |
| ORD ID | ord-9bb7a49ccb15458eb06d178ed62e3219 |
| 出典メモ | uspto-grants-1979_04 |