化工社化工社 化学情報印刷レポート · 研究参考用
2-Hydroxy-4-Methoxybenzaldehyde → 3-Nicotinoyl-7-methoxycoumarin
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 2-Hydroxy-4-Methoxybenzaldehyde | HCID 69600 | — |
| 反応物 | Ethyl 3-oxo-3-(pyridin-3-yl)propanoate | HCID 222197 | — |
| 触媒 | Piperidine | HCID 8082 | — |
| 生成物 | 3-Nicotinoyl-7-methoxycoumarin | HCID 21217331 | — |
反応手順
A mixture of 0.65 g ethyl nicotinoylacetate, 0.5 g 2-hydroxyanisaldehyde and 10 ml alcohol was heated on a steam bath until solution was attained. Five drops of piperdine were added and heating was continued. After several minutes the reaction mixture solidified. An additional 10 ml of alcohol were added and the reaction mixture heated another 15 minutes. After cooling, the solid was collected and recrystallized twice from a mixture of alcohol and acetonitrile.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04147552 |
| 出典データセット | uspto-grants-1979_04 |
| ORD ID | ord-0df72b8e35584857b395332273362433 |
| 出典メモ | uspto-grants-1979_04 |