Methanol → 1,3-Bis(2-hydroxyethylthio)propane

The sodium mercaptide of 2-mercaptoethanol was made by reacting 1 mole each of sodium methoxide and 2-mercaptoethanol in dry methanol under a nitrogen atmosphere. To this solution, 0.5 mole of 1,3-dichloropropane was added and the mixture was refluxed for 1 hour and filtered. The methanol filtrate was evaporated on a flash evaporator and traces of 2-mercaptoethanol were distilled off at high vacuum at room temperature. The yellow, oily residue was extracted with acetone, the solution filtered, and the acetone evaporated to give a 95 percent yield of the crude product.

1. temperaturethe mixture was refluxed for 1 hour
2. filtrationfiltered
3. customThe methanol filtrate was evaporated on a flash evaporator and traces of 2-mercaptoethanol
4. distillationwere distilled off at high vacuum at room temperature
5. extractionThe yellow, oily residue was extracted with acetone
6. filtrationthe solution filtered
7. customthe acetone evaporated

ORDレコード

ord-b8a27b8a1a794ffebfedb31a6d6eee9a

出典データセット

uspto-grants-1977_07

DOI

10.6084/m9.figshare.5104873.v1

特許番号

USRE029305