Hydrochloric Acid → 4-{[4-(Diphenylmethyl)-1-piperidinyl]methyl}benzenamine dihydrochloride

HRID 258822ノート

反応式

HRID 258822 の反応式
[C:1]1([CH:7]([C:22]2[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=2)[CH:8]2[CH2:13][CH2:12][N:11]([CH2:14][C:15]3[CH:20]=[CH:19][C:18]([NH2:21])=[CH:17][CH:16]=3)[CH2:10][CH2:9]2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.CO.[ClH:30].CCOCC>CC(O)C>[ClH:30].[ClH:30].[C:22]1([CH:7]([C:1]2[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=2)[CH:8]2[CH2:9][CH2:10][N:11]([CH2:14][C:15]3[CH:16]=[CH:17][C:18]([NH2:21])=[CH:19][CH:20]=3)[CH2:12][CH2:13]2)[CH:23]=[CH:24][CH:25]=[CH:26][CH:27]=1

参加物

6

反応物 4

HCID 313Hydrochloric AcidHCID 887MethanolHCID 3283Diethyl EtherHCID 202258204-{[4-(Diphenylmethyl)-1-piperidinyl]methyl}benzenamine

生成物 1

HCID 214248464-{[4-(Diphenylmethyl)-1-piperidinyl]methyl}benzenamine dihydrochloride

試薬・触媒・溶媒 1

HCID 3776Isopropanol溶媒

実験手順

To a solution of 5 parts of 4-{[4-(diphenylmethyl)-1-piperidinyl]methyl}benzenamine in 40 parts of methanol is added 4 parts of a 30% solution of hydrogen chloride in 2-propanol, whereupon just sufficient anhydrous ether is introduced to induce precipitation. The precipitate is filtered off and recrystallized from a mixture of methanol and ether to give 4-{[4-(diphenylmethyl)-1-piperidinyl]methyl}benzenamine dihydrochloride melting at 233°-237° with gas evolution. The product has the formula ##STR4##

後処理

  1. customprecipitation
  2. filtrationThe precipitate is filtered off
  3. customrecrystallized from a mixture of methanol and ether

出典と根拠

ORDレコード
ord-66bb40405f9c456d8ffad1fd4818984e
出典データセット
uspto-grants-1977_07
特許番号
US04035372

反応ノート

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