Hydrochloric Acid → HCID 21424809、化合物

HRID 258830ノート

反応式

HRID 258830 の反応式
[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([Cl:8])=[CH:4][C:3]=1[NH:9][CH2:10][CH2:11][OH:12].N[C:14](N)=[O:15].Cl>O>[Cl:8][C:5]1[CH:6]=[CH:7][C:2]2[NH:1][C:14](=[O:15])[N:9]([CH2:10][CH2:11][OH:12])[C:3]=2[CH:4]=1

参加物

5

反応物 3

HCID 313Hydrochloric AcidHCID 1176UreaHCID 10702726HCID 10702726、化合物

生成物 1

HCID 21424809HCID 21424809、化合物収率 57.1%

試薬・触媒・溶媒 1

HCID 962Water溶媒

反応条件

温度
190 °C

実験手順

A mixture of 20 parts of 2-[(2-amino-5-chlorophenyl)-amino]ethanol and 18 parts of urea is stirred and heated for 4 hours in an oil-bath at about 190° C. The reaction mixture is cooled and dissolved in alkaline water. The solution is acidified with a concentrated hydrochloric acid solution. The precipitated product is filtered off, washed with water and dried, yielding 13 parts (57.1%) of 6-chloro-1,3-dihydro-1-(2-hydroxyethyl)-2H-benzimidazol-2-one; mp. 160° C.

後処理

  1. temperatureThe reaction mixture is cooled
  2. filtrationThe precipitated product is filtered off
  3. washwashed with water
  4. customdried

出典と根拠

ORDレコード
ord-673e3c51d089484e8ce1f61600d22129
出典データセット
uspto-grants-1977_07
特許番号
US04035369

反応ノート

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