Hydrochloric Acid → Ethyl p-(2-thenoyl)hydratropate

HRID 258888

反応式

HRID 258888 の反応式
[C:1]1([C:6]([C:8]2[CH:18]=[CH:17][C:11]([CH:12]([CH3:16])[C:13]([OH:15])=[O:14])=[CH:10][CH:9]=2)=[O:7])[S:5][CH:4]=[CH:3][CH:2]=1.Cl.[CH2:20](O)[CH3:21]>>[C:1]1([C:6]([C:8]2[CH:18]=[CH:17][C:11]([CH:12]([CH3:16])[C:13]([O:15][CH2:20][CH3:21])=[O:14])=[CH:10][CH:9]=2)=[O:7])[S:5][CH:4]=[CH:3][CH:2]=1

参加物

4

反応物 3

HCID 313Hydrochloric AcidHCID 702EthanolHCID 5359Suprofen

生成物 1

HCID 12232951Ethyl p-(2-thenoyl)hydratropate

実験手順

A mixture of 5.2 parts of p-(2-thenoyl)hydratropic acid, 40 parts of absolute denatured ethanol and 0.5 parts of hydrochloric acid solution is stirred and refluxed for 24 hours. The reaction mixture is evaporated and the residue is taken up in ether. The ethereal solution is shaken with alkaline water, separated and shaken twice with water. The ether phase is dried, filtered and evaporated, yielding ethyl p-(2-thenoyl)hydratropate, also named ethyl p-(2-thenoyl)-α-methyl-phenylacetate, as a residue.

後処理

  1. temperaturerefluxed for 24 hours
  2. customThe reaction mixture is evaporated
  3. stirringThe ethereal solution is shaken with alkaline water
  4. customseparated
  5. stirringshaken twice with water
  6. dry with materialThe ether phase is dried
  7. filtrationfiltered
  8. customevaporated

出典と根拠

ORDレコード
ord-925f1d235b844c00a8f0250c8471af8f
出典データセット
uspto-grants-1977_07
特許番号
US04035376

関連ノート

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