Hydrochloric Acid → Suprofen

HRID 258902

反応式

HRID 258902 の反応式
CC(N)C1C=CC=CC=1.[C:10]1([C:15]([C:17]2[CH:27]=[CH:26][C:20]([CH:21]([CH3:25])[C:22]([OH:24])=[O:23])=[CH:19][CH:18]=2)=[O:16])[S:14][CH:13]=[CH:12][CH:11]=1.Cl>O>[C:10]1([C:15]([C:17]2[CH:27]=[CH:26][C:20]([CH:21]([CH3:25])[C:22]([OH:24])=[O:23])=[CH:19][CH:18]=2)=[O:16])[S:14][CH:13]=[CH:12][CH:11]=1

参加物

4

反応物 2

HCID 313Hydrochloric AcidHCID 70638167(+)-p-(2-Thenoyl)hydratropic acid alpha-methylbenzylamine

生成物 1

HCID 5359Suprofen

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

1.5 Parts of (-)-p-(2-thenoyl)hydratropic acid α-methyl-benzylamine are suspended in water and acidified with hydrochloric acid. The product is extracted with ether. The organic layer is washed with water, dried and evaporated. The oily residue solidifies on triturating in petroleumether. The solified product is filtered off and dried in vacuo at 50° C, yielding (+)-p-(2-thenoyl)hydratropic acid; [α] (1% in MeOH) = +44.5°.

後処理

  1. extractionThe product is extracted with ether
  2. washThe organic layer is washed with water
  3. customdried
  4. customevaporated
  5. customon triturating in petroleumether
  6. filtrationThe solified product is filtered off
  7. customdried in vacuo at 50° C

出典と根拠

ORDレコード
ord-05456246330d4b0294a5e89fa2698254
出典データセット
uspto-grants-1977_07
特許番号
US04035376

関連ノート

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