Ethanol → (+)-p-(2-Thenoyl)hydratropic acid alpha-methylbenzylamine

HRID 258903

反応式

HRID 258903 の反応式
[C:1]1([C:6]([C:8]2[CH:18]=[CH:17][C:11]([CH:12]([CH3:16])[C:13]([OH:15])=[O:14])=[CH:10][CH:9]=2)=[O:7])[S:5][CH:4]=[CH:3][CH:2]=1.[CH3:19][CH:20]([NH2:27])[C:21]1[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=1.C(O)C>O>[CH3:19][CH:20]([NH2:27])[C:21]1[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=1.[C:1]1([C:6]([C:8]2[CH:18]=[CH:17][C:11]([CH:12]([CH3:16])[C:13]([OH:15])=[O:14])=[CH:10][CH:9]=2)=[O:7])[S:5][CH:4]=[CH:3][CH:2]=1

参加物

5

反応物 3

HCID 702EthanolHCID 5359SuprofenHCID 74081-Phenethylamine

生成物 1

HCID 70638167(+)-p-(2-Thenoyl)hydratropic acid alpha-methylbenzylamine

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

To a stirred mixture of 30 parts of p-(2-thenoyl)hydratropic acid and 14 parts of (+)-α-methylbenzylamine in 200 parts of ethanol are added 50 parts of water. The precipitated salt is filtered off and crystallized from a mixture of ethanol and water (10 : 2 by volume), yielding the crude salt form. This fraction is recrystallized several times till constant rotation, from a mixture of ethanol and water (10 : 2 by volume), yielding (+)-p-(2-thenoyl)hydratropic acid α-methylbenzylamine; mp. 171.1° C.; [α] (2.02% MeOH) = +13.55°.

後処理

  1. filtrationThe precipitated salt is filtered off
  2. customcrystallized from a mixture of ethanol and water (10 : 2 by volume)
  3. customyielding the crude salt form
  4. customThis fraction is recrystallized several times till constant rotation
  5. additionfrom a mixture of ethanol and water (10 : 2 by volume)

出典と根拠

ORDレコード
ord-9c14d9053a204a39b4957ed8dcdc8e42
出典データセット
uspto-grants-1977_07
特許番号
US04035376

関連ノート

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