Hydrochloric Acid → Suprofen

HRID 258904

反応式

HRID 258904 の反応式
CC(N)C1C=CC=CC=1.[C:10]1([C:15]([C:17]2[CH:27]=[CH:26][C:20]([CH:21]([CH3:25])[C:22]([OH:24])=[O:23])=[CH:19][CH:18]=2)=[O:16])[S:14][CH:13]=[CH:12][CH:11]=1.Cl>O>[C:10]1([C:15]([C:17]2[CH:27]=[CH:26][C:20]([CH:21]([CH3:25])[C:22]([OH:24])=[O:23])=[CH:19][CH:18]=2)=[O:16])[S:14][CH:13]=[CH:12][CH:11]=1

参加物

4

反応物 2

HCID 313Hydrochloric AcidHCID 70638167(+)-p-(2-Thenoyl)hydratropic acid alpha-methylbenzylamine

生成物 1

HCID 5359Suprofen

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

1 part of (+)-p-(2-thenoyl)hydratropic acid α-methylbenzylamine is suspended in water and acidified with hydrochloric acid. The product is extracted with ether. The organic layer is washed with water, dried, filtered and evaporated in vacuo. The oily residue solidifies on triturating in petroleumether. The solidified product is filtered off and dried in vacuo at 50° C, yielding (-)-p-(2-thenoyl)hydratropic acid; [α] (1% MeOH) =MeOH)= -45.6°.

後処理

  1. extractionThe product is extracted with ether
  2. washThe organic layer is washed with water
  3. customdried
  4. filtrationfiltered
  5. customevaporated in vacuo
  6. customon triturating in petroleumether
  7. filtrationThe solidified product is filtered off
  8. customdried in vacuo at 50° C

出典と根拠

ORDレコード
ord-2c53f8e24b814c87a7c9ecb3767b3d63
出典データセット
uspto-grants-1977_07
特許番号
US04035376

関連ノート

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