Benzaldehyde → 2,2,4-Triphenyl-butane-1,4-dione

HRID 258945

反応式

HRID 258945 の反応式
[CH:1](=[CH:8][C:9]([C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1)=[O:10])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.C(=O)[C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1.CN(C)[CH:27]=[O:28]>C(N(CC)CC)C>[C:2]1([C:1]([C:18]2[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=2)([CH2:8][C:9]([C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=2)=[O:10])[CH:27]=[O:28])[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

参加物

5

反応物 3

HCID 240BenzaldehydeHCID 6228DimethylformamideHCID 7189Cinnamoylbenzene

生成物 1

HCID 214250622,2,4-Triphenyl-butane-1,4-dione

試薬・触媒・溶媒 1

HCID 8471Triethylamine溶媒

反応条件

温度
80 °C

実験手順

Following the procedure described in Example 1, 57.2 g (0.275 mol) of benzylideneacetophenone, 29.2 g of benzaldehyde, 25.1 g (0.1 mol) of Catalyst 2 and 400 ml of dimethylformamide are introduced successively into the 500 ml three-necked flask and after stirring for 15 minutes under nitrogen 40.4 g (0.4 mol) of triethylamine are added. The mixture is then heated to 80° C for 12 hours. For working up, the dimethylformamide is distilled off and 150 ml of isopropanol are added to the residue while it is still hot. The product which has precipitated is filtered off, washed with isopropanol and then dried. 2,2,4-Triphenyl-butane-1,4-dione is obtained.

後処理

  1. additionare introduced successively into the 500 ml three-necked flask
  2. additionare added
  3. distillationthe dimethylformamide is distilled off
  4. addition150 ml of isopropanol are added to the residue while it
  5. customThe product which has precipitated
  6. filtrationis filtered off
  7. washwashed with isopropanol
  8. customdried

出典と根拠

ORDレコード
ord-091d27a4e217419a895418ea1b77f057
出典データセット
uspto-grants-1977_07
特許番号
US04035395

関連ノート

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